Clinical Data Research Networks

Clinical Data Tools
Duke Dataset Inventory
Population Health Data Sets
EHR Data Consultation Services

Duke participates in several Clinical Data Research Networks (CDRNs), making it easier to conduct multi-site research by allowing potential access to EHR data at all member institutions, including Duke.

Benefits of leveraging the CDRN program:

  • Quickly get counts of patients meeting your inclusion/exclusion criteria
  • Assess feasibility of multi-site studies
  • Find collaborators at other member institutions
  • Navigate the associated regulatory processes

Our team can help you learn about the Duke CDRN program and the process for accessing CDRN resources. Contact us to get started with clinical data.


CDRNs available to Duke investigators

 STAR Clinical Research Network (formerly Mid-South CDRN)

  • Scope: Local, Regional, and National
  • Population: >14 million
  • Who is Involved: Duke University Health System; Mayo Clinic; Vanderbilt University Medical Center; Meharry Medical College; UNC-Chapel Hill; Wake Forest Baptist Health

Through this network, we have access to a broad array of clinical data, informatics tools, patients, providers, and systems to address an array of research questions. The objective of our CRN is to robustly support comparative effectiveness studies, pragmatic clinical trials, health system innovation, and the other research needs of our stakeholders and partners.

  ACT Network logo ACT Network at Duke (i2b2)

  • Scope: Local and National
  • Population: ~100 M
  • Who Is Involved: 39 CTSA institutions (18 more currently staging)

The ACT Network is a real-time platform allowing researchers to explore and validate feasibility for clinical studies from the comfort of their desktop.

Use ACT to discover patient cohorts at Duke and more than 32 sites across the nation. Duke CTSI has made the ACT Network available to all Duke researchers at no cost, but you must request access to receive credentials in the ACT portal.

Request access here.

Once registration is complete and you have received your credentials, you can use i2b2 to query Duke EHR-data and SHRINE to query Duke and the entire network for aggregate counts.

ACT was developed collaboratively by members of NCATS’ Clinical and Translational Science Award (CTSA) Consortium, with funding from the NIH National Center for Advancing Translational Sciences.

Have questions about ACT? Email

  Carolinas Collaborative logo Carolinas Collaborative

  • Scope: Regional (NC, SC)
  • Population: ~12 M Patients
  • Who Is Involved: Duke, UNC-CH, Wake Forest, Health Sciences South Carolina

This is a collaboration between four different health care organizations in North and South Carolina, who have agreed to share their clinical data in a federated manner to support clinical research. The Carolinas Collaborative is funded by the Duke Endowment.