Duke/RTI Collaborative Translational Research Grants - Request for Applications 2020-2021

January 23, 2020


Mandatory Letter of Intent:  11:59 p.m. ET, May 21, 2020

Invitation for Full Application Deadline: 11:59 p.m. ET, August 5, 2020

View the RFA

This pilot program is designed to facilitate novel clinical and translational research that applies or accelerates discovery into testing in clinical or population settings. Projects will advance solutions by applying discoveries generated during research in the laboratory, and in preclinical studies in the areas of medicinal chemistry, computational chemistry, High Throughput Screening (HTS) and assay development, in vitro absorption–distribution–metabolism–excretion–toxicity (ADMET) and pharmacology and in vivo pharmacokinetics in clinical or population settings.

The Duke Clinical and Translational Science Institute (Duke CTSI) is the academic home of the National Institutes of Health’s Clinical and Translational Science Awards (CTSA) pilot funding programs at Duke University, is partnering with RTI International (RTI) to support new inter-institutional collaborative research teams. 

Duke CTSI and RTI are interested in the following types of translational research projects that foster collaboration between the two institutions:

  • Research that generates translational discoveries relevant to human health or disease, regardless of whether the context of the discovery is the laboratory, in animal models or the field.
  • Research that applies or accelerates discovery into testing in clinical or population settings.

Key Dates

  • Mandatory Letter of Intent (LOI): May 21, 2020
  • Invited LOI Presentation/Consultation: June-July 2020
  • Invited Application Submission Deadline: August 5, 2020
  • Selection of Awardees: September 2020
  • Funding Period: The budget period is for 12 months beginning October 1, 2020 – September 30, 2021

Eligibility Requirements

  • Proposed projects must involve a lead investigator from Duke (full-faculty appointment) and a lead investigator from RTI. Proposals are encouraged from new teams of investigators from different disciplines.  An RTI investigator will be identified to collaborate on invited applications following the LOI presentation.
  • More than one proposal may be submitted by a Duke Faculty member acting as PI, but the Duke Faculty member is only eligible to receive one award as PI from this funding mechanism during a given funding cycle.
  • Submission of mandatory LOI (see section VII. For submission instructions).
  • Completion of proposal presentation to CTSI and RTI for selected LOI applicants. Upon conclusion of the presentation you will be connected with a RTI investigator to collaborate on Full Application Submission, if invited.


The research activities at each participating institution will be funded by the Duke CTSI and RTI.  The Duke CTSI and RTI will fund up to $50,000 per award ($25,000 per institution).

Note for Duke Investigators: This award is internally funded and does not need to be routed through ORA.

Proposal Preparation

The CTSI and RTI strongly recommend involving a biostatistician in the invited full application development process. The online application form will ask for the name of the biostatistician who consulted on the proposal. Investigators without access to a biostatistician can request support through the Duke CTSI Biostatistics Core by submitting a Core Resource Request form.

A consult with CTSI is recommended.

Letter of Intent and Application Procedure

The Letter of Intent (LOI) will be submitted via Duke’s MyResearchProposal online submission system.​

View the RFA for full application instructions


For additional information on this funding opportunity, please contact Tarun Saxena at CTSIfunding@duke.edu. To schedule a consultation, contact Anita Grissom at consultstudio@duke.edu.