2015 Transformative Award

Project Title: Commercial-Grade cGMP Manufacture of the Oncolytic Poliovirus Chimera, PVSRIPO

Principal Investigator: Matthias Gromeier, PhD, Associate Professor, Department of Neurosurgery

This project proposes to establish commercial-grade (CMO) manufacture of the oncolytic poliovirus, PVSRIPO, to enable continued clinical investigation and translation of a promising new cancer immunotherapy platform. PVSRIPO is currently being tested and showing promise in Phase-1 clinical trials at the Duke Cancer Institute against recurrent glioblastoma (GBM).