2015 Fall Voucher Awards

The 2015 Fall SOM Core Facility Voucher Program was a joint program with the School of Medicine (SOM), the Duke Translational Research Institute (DTRI) Pilot Program and the Office of the Provost. The following investigators recieved vouchers:

 

Principal Investigator: Anne D. Yoder, Biology, Arts and Sciences

Project Title: Whole transcriptome analysis following hypoxia, a comparative study between lemur and human

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Arno L. Greenleaf, Biochemistry Department

Project Title: “Identification of BRCA1 synthetic lethal genes via Microarray analysis of genome-wide shRNA screens

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Charles  Gersbach, Biomedical Engineering

Project Title: Protein Interactome Analysis of Synthetic Epigenome Editing Tools

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI), Proteomics Core Facility (GCB/DCI)

 

Principal Investigator: Christopher L. Holley, Department of Medicine

Project Title: Novel approaches for the study of cardiovascular snoRNA

Cores to be used: BAC Recombineering Core Facility (DCI), Transgenic and Knock Out Mouse Shared Resource (DCI)

 

Principal Investigator: Deverick J. Anderson, Medicine

Project Title: The molecular epidemiology of MDR E. coli and Klebsiella using whole genome sequencing

Cores to be used: Molecular Genomics Core Facility (DMPI)

 

Principal Investigator: Donald McDonnell,

Project Title: Understanding 27HC in breast cancer biology using a genome-wide CRISPR Screen in a mouse model

Cores to be used: DLAR Breeding Core, Optical Molecular Imaging and Analysis Shared Resource (DCI)

 

Principal Investigator: Dorothy Sipkins, Associate Professor

Project Title: Transcriptional profiling of spinal cord infiltrates in acute lymphoblastic leukemia

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Dr. John Sampson, Neurosurgery

Project Title: Identifying the factors of in vitro-derived dendritic cells that mediate enhanced immunogenicity

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Jorn Coers, Molecular Genetics and Microbiology

Project Title: Development of a novel mouse model to study the role of IRGM in colitis and septic shock

Cores to be used: BAC Recombineering Core Facility (DCI), DLAR Breeding Core

 

Principal Investigator: Lisa L. Satterwhite, Biomedical Engineering, Pratt School of Engineering, Duke University

Project Title: A Novel Blood-based Diagnostic for Early Stage Pancreatic Cancer

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Megan E. B. Clowse, Medicine

Project Title: A pilot study of the Aspirin Response Signature as a marker of preeclampsia risk in women with lupus

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Meta Kuehn, Biochemistry

Project Title: Quantification of Pseudomonas aeruginosa cell biofilms on human lung cells

Cores to be used: Duke Univeristy Light Microscope Core Facility

 

Principal Investigator: Nicolas Buchler, Biology

Project Title: Transcriptomics in a non-model organism:  Viral hijacking of an ancestral fungal cell cycle

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Ornit Chiba-Falek, Associate Professor of Neurology

Project Title: Tri-SNCA iPSC-derived cell lines for studying the effect of SNCA overexpression on synucleinopathies

Cores to be used: IPSC Shared Resource Facility

 

Principal Investigator: Paul Magwene, Biology

Project Title: Characterizing the effects of genetic variation on osmo-signaling dynamics in yeast

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Pei Zhou, Biochemistry

Project Title: Crystallographic Studies of a Novel Antibiotic Target in Lipid A Biosynthesis

Cores to be used: Duke Macromolecular X-ray Crystallography Shared Resource (DHVI)

 

Principal Investigator: Rasheed Gbadegesin, Pediatrics

Project Title: Characterizing the Role of Rare IL-15R Variants in the Pathogenesis of Focal Segmental Glomeruloscl

Cores to be used: Biomolecular Interaction Analysis Facility (DHVI)

 

Principal Investigator: Ravi Karra, Medicine/Cardiology

Project Title: Genetic Tools to Dissect Mammalian Heart Regeneration

Cores to be used: Transgenic and Knock Out Mouse Shared Resource (DCI)

 

Principal Investigator: Rebecca Y. Klinger, Anesthesiology

Project Title: Intravenous Lidocaine for Myocardial Protection during Cardiac Surgery with Cardiopulmonary Bypass

Cores to be used: Biomarkers Shared Resource (DMPI)

 

Principal Investigator: Sallie Permar, Pediatrics

Project Title: Placental dysregulation and inflammation in severe congenital cytomegalovirus infection

Cores to be used: Sequencing and Genomic Technologies (GCB/DCI)

 

Principal Investigator: Scott Floyd, Radiation Oncology

Project Title: Project BrainTumorSlice: Screening for chemo-radiosensitizaiton targets in 3-D models of glioma

Cores to be used: RNAi Facility (MGM)

 

Principal Investigator: Steve Taylor, Medicine-ID

Project Title: Spatial clustering of P. falciparum malaria parasite transmission

Cores to be used: DNA Analysis Facility (Immunology)

 

Principal Investigator: Terrence G. Oas, Biochemistry

Project Title: Structural & Functional Studies of Staphylococcal Protein A

Cores to be used: High Resolution NMR Shared Resource (DCI)

 

Principal Investigator: Vadim Arshavsky, Ophthalmology

Project Title: Generation of an inducible non-cleavable protocadherin 21 knockin mouse

Cores to be used: Transgenic and Knock Out Mouse Shared Resource (DCI)

 

Principal Investigator: Wenge Liu, Biomedical Engineering

Project Title: Injectable Brachytherapy Enhances EPR Effect by Modifying Tumor Microenvironment

Cores to be used:

 

Principal Investigator: Xiao-Fan Wang, Pharmacology and Cancer Biology

Project Title: Discovery of a novel protease involved in cellular senescence by using SILAC based MS

Cores to be used: GCB Proteomics and metabolomics