The National Institutes of Health (NIH) Health Care Systems Research Collaboratory (Collaboratory) aims to strengthen the national capacity to implement cost-effective large-scale research studies that engage healthcare delivery organizations as research partners.
The Coordinating Center of the NIH Collaboratory is based at the Duke Clinical Research institute (part of the CTSI). The Coordinating Center supports:
- Pragmatic clinical trial Demonstration Projects that address questions of major public health importance and engage healthcare delivery systems in research partnerships. These projects help to establish best practices and provide proof of concept for innovative designs in pragmatic clinical research.
- A Living Textbook of Pragmatic Clinical Trials, an online textbook that reflects a collection of knowledge from the Collaboratory, including expert consensus regarding special considerations, standard approaches, and best practices in the design, conduct, and reporting of pragmatic clinical trials.
- Five Cores/Working Groups—focused on biostatistics and study design, electronic health records, healthcare systems interactions, ethical/regulatory issues, and patient-reported outcomes—that support all of the Demonstration Projects and generate guidance addressing implementation challenges.
- A Distributed Research Network that enables investigators to collaborate in the use of electronic health data while safeguarding protected health information.
- Grand Rounds, a weekly webinar series on issues related to pragmatic research.
The NIH Collaboratory is supported by the National Center for Complementary & Integrative Health of the National Institutes of Health.